Intern, Early Development – Investigative Toxicology
Early Development – Investigative Toxicology Intern
Overview
Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with unmet need. Our first medicine, the first-ever RNAi therapeutic, has recently been approved by the FDA in the US for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and by the European Medicines Agency in the EU for the treatment of hATTR amyloidosis in adults with stage 1 or stage 2 polyneuropathy. In addition, Alnylam has four investigational medicines in late-stage development. www.alnylam.com. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work in 2015, 2016, 2017 and 2018- four years in a row!
Alnylam is seeking a highly motivated intern with introductory biology, biochemistry and/or toxicology experience, and proven abilities in the execution, analysis, interpretation, and communication of in vitro cellular and molecular biology assays. The candidate will engage in a variety of lab-based investigative, mechanistic siRNA research efforts related to the preclinical safety and efficacy evaluation of novel RNAi therapeutic modalities. The individual will work closely with the Research, Toxicology, Pathology, and DMPK groups.
Learning Objectives
- Learning Objective #1: Establish culture of multiple commercially-available neuronal cell lines
- Learning Objective #2: Assess free uptake and activity of C16-siRNA across these cell lines
- Learning Objective #3: Knock down candidate receptors and test the effects on C16-siRNA uptake and activity
Qualifications
- You must be legally eligible to work in the U.S.
- Must be currently enrolled in Bachelors, Masters or PhD program
- 1+ years of hands-on lab experience with molecular and/or cellular biology techniques
Benefits/Additional Information
- Alnylam Interns are eligible for the T-Pass/public transit and Leanbox benefits
- Office located in Cambridge (Kendall Square), assessible by MBTA
- Various lunch & learns, forums, and seminars hosted by the company, providing opportunities to gain greater knowledge of the pharmaceutical world and current research topics.
- Alnylam offers interns a competitive hourly rate through our payroll department
- Alnylam does NOT pay or reimburse for any living costs associated with the internship program
Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.